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    Vesicle sub-pool organization at inner hair cell ribbon synapses.
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  • Magalhães RSS, Popova B, Braus GH, Outeiro TF, Eleutherio ECA.
    The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.
    FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy066. (PubMed)
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    Parahydrogen-Based Hyperpolarization for Biomedicine.
    Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201711842. (PubMed)
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    Carbon Nanotubes Encapsulated in Coiled-Coil Peptide Barrels.
    Chem. Eur. J. 2018, DOI: 10.1002/chem.201800993. Cover feature (PubMed)
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    Nuclear spin singlet states as magnetic on/off probes in self-assembling systems.
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    Membrane binding, internalization, and sorting of alpha-synuclein in the cell.
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    De novo designed α-helical coiled-coil peptides as scaffolds for chemical reactions.
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    Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
    Neurobiol Dis. 2018 Aug 6;119:121-135. doi: 10.1016/j.nbd.2018.08.001. (PubMed)
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    Over 50 % 1H and 13C Polarization for Generating Hyperpolarized Metabolites—A para‐Hydrogen Approach.
    ChemistryOpen. 2018, DOI: 10.1002/chem.201800086. (Wiley online library)
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    X10 expansion microscopy enables 25-nm resolution on conventional microscopes.
    EMBO Rep. 2018 Jul 9. pii: e45836. doi: 10.15252/embr.201845836. (PubMed)
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    Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
    EMBO J. 2018 Aug 1;37(15). pii: e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27. (PubMed)
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    Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
    Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print] (PubMed)
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    More Than 12% Polarization and 20 Minutes Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water.
    Angew. Chem. Int. Ed. 2018, 57, 10692-10696. (PubMed)
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    miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.
    Mol Ther Nucleic Acids. 2018 Jun 1;11:9-22. doi: 10.1016/j.omtn.2018.01.005. Epub 2018 Feb 2. (PubMed)
  • Vaz RL, Outeiro TF, Ferreira JJ.
    Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review.
    Front Neurol. 2018 Jun 1;9:347. doi: 10.3389/fneur.2018.00347. eCollection 2018. (PubMed)
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    Pulsed Magnetic Resonance to Signal-Enhance Metabolites within Seconds by utilizing para-Hydrogen.
    ChemistryOpen. 2018 May 8;7(5):344-348. doi: 10.1002/open.201800024. eCollection 2018 May. (PubMed)
  • Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE,Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN.
    (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.
    Sci Rep. 2018 May 3;8(1):6965. doi: 10.1038/s41598-018-25118-z. (PubMed)
  • Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.
    The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
    Mol Neurobiol. 2018 Apr 19. doi:10.1007/s12035-018-1084-y. (PubMed)
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    Kinetic Studies on Strand Displacement in de novo Designed Parallel Heterodimeric Coiled Coils.
    Chem. Sci. 2018, 9, 4308–4316. (PubMed)
  • Biosa A, Outeiro TF, Bubacco L, Bisaglia M.
    Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View.
    Mol Neurobiol. 2018 Mar 28. doi: 10.1007/s12035-018-1025-9. [Epub ahead of print] Review. (PubMed)
  • Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO.
    Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.
    Biophys J. 2018 Mar 13;114(5):1036-1045. doi: 10.1016/j.bpj.2018.01.003. (PubMed)
  • Fourcade S, Outeiro TF, Pujol A.
    SIRT2 in age-related neurodegenerative disorders.
    Aging (Albany NY). 2018 Mar 3;10(3):295-296. doi:10.18632/aging/101397. (PubMed)
  • König A, Vicente Miranda H, Outeiro TF.
    Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease.
    J Parkinsons Dis. 2018;8(1):33-43. doi: 10.3233/JPD-171285. (PubMed)
  • Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, Wichmann C, Strenzke N, Grabner C, Moser T.
    The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
    Elife. 2018 Jan 12;7. pii: e29275. doi: 10.7554/eLife.29275. (PubMed)
  • Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C,Meyer T.
    Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study.
    World J Biol Psychiatry. 2018 Jan 11:1-9. doi: 10.1080/15622975.2017.1417636. [Epub ahead of print] (PubMed)
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    Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
    EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.(PubMed)
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    Guidelines and recommendations on yeast cell death nomenclature.
    Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review. (PubMed)


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    Correction: Gene Expression Differences in Peripheral Blood of Parkinson’s Disease Patients with Distinct Progression Profiles.
    PLoS One. 2017 Dec 28;12(12):e0190552. doi: 10.1371/journal.pone.0190552. eCollection 2017 (PubMed)
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    The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus.
    Diabetol Metab Syndr. 2017 Dec 4;9:97. doi: 10.1186/s13098-017-0295-0. eCollection 2017. (PubMed)
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    Building Bridges through Science.
    Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028. (PubMed)
  • Krinner S, Butola T, Jung S, Wichmann C, Moser T.
    RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.
    Front Cell Neurosci. 2017 Nov 2;11:334. doi: 10.3389/fncel.2017.00334. eCollection 2017. (PubMed)
  • Lemos V, de Oliveira RM, Naia L, Szegö É, Ramos E, Pinho S, Magro F, Cavadas C, Rego AC, Costa V, Outeiro TF, Gomes P.
    The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
    Hum Mol Genet. 2017 Nov 1;26(21):4105-4117. doi: 10.1093/hmg/ddx298. (PubMed)
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    Serum lipid alterations in GBA-associated Parkinson’s disease.
    Parkinsonism Relat Disord. 2017 Nov;44:58-65. doi: 10.1016/j.parkreldis.2017.08.026. Epub 2017 Sep 1. (PubMed)
  • López-León M, Outeiro TF, Goya RG.
    Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain.
    Ageing Res Rev. 2017 Nov;40:168-181. doi: 10.1016/j.arr.2017.09.002. Epub 2017 Sep 10. Review. (PubMed)
  • Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.
    α-synuclein interacts with PrP(C) to induce cognitive impairment through mGluR5 and NMDAR2B.
    Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25. (PubMed)
  • Butola T, Wichmann C, Moser T.
    Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.
    Front Synaptic Neurosci. 2017 Oct 25;9:14. doi: 10.3389/fnsyn.2017.00014. eCollection 2017. (PubMed)
  • Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF.
    Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease.
    Sci Rep. 2017 Oct 20;7(1):13713. doi: 10.1038/s41598-017-14175-5. (PubMed)
  • Roodveldt C, Outeiro TF, Braun JEA.
    Editorial: Molecular Chaperones and Neurodegeneration.
    Front Neurosci. 2017 Oct 11;11:565. doi: 10.3389/fnins.2017.00565. eCollection 2017. (PubMed)
  • Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.
    Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.
    Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260. (PubMed)
  • Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA.
    Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.
    Mol Neurobiol. 2018 Jun;55(6):5269-5281. doi: 10.1007/s12035-017-0755-4. Epub 2017 Sep 7. (PubMed)
  • Correia Guedes L, Reimão S, Paulino P, Nunes RG, Bouça-Machado R, Abreu D, Gonçalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, Campos J, Outeiro TF, Sampaio C, Bonifati V, Ferreira JJ.
    Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson’s disease.
    Mov Disord. 2017 Sep;32(9):1331-1333. doi: 10.1002/mds.27083. Epub 2017 Jul 7. (PubMed)
  • Gomes de Castro MA, Höbartner C, Opazo F.
    Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy.
    PLoS One. 2017 Feb 24;12(2):e0173050. doi: 10.1371/journal.pone.0173050. eCollection 2017. (PubMed)


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    Tools and limitations to study the molecular composition of synapses by fluorescence microscopy.
    Biochem J. 2016 Oct 15;473(20):3385-3399. Review. (PubMed)