Publications

2019

  • Sampaio-Marques B, Guedes A, Vasilevskiy I, Gonçalves S, Outeiro TF, Winderickx J, Burhans WC, Ludovico P.
    α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1.
    Aging Cell. 2019 Aug;18(4):e12922. doi: 10.1111/acel.12922. Epub 2019 Apr 11.(PubMed)
  • Ferreira C, Couceiro J, Família C, Jardim C, Antas P, Santos CN, Outeiro TF, Tenreiro S, Quintas A.
    The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism.
    FEMS Yeast Res. 2019 Aug 1;19(5). pii: foz042. doi: 10.1093/femsyr/foz042.(PubMed)
  • Markworth R, Adolfs Y, Dambeck V, Steinbeck LM, Lizé M, Pasterkamp RJ, Bähr M, Dean C, Burk K.
    Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling.
    J Neurosci. 2019 Jul 24;39(30):5842-5860. doi: 10.1523/JNEUROSCI.0027-19.2019. Epub 2019 May 23.(PubMed)
  • Paiva I, Carvalho K, Santos P, Cellai L, Pavlou MAS, Jain G, Gnad T, Pfeifer A, Vieau D, Fischer A, Buée L, Outeiro TF, Blum D.
    A2A R-induced transcriptional deregulation in astrocytes: An in vitro study.
    Glia. 2019 Jul 22. doi: 10.1002/glia.23688. [Epub ahead of print](PubMed)
  • Brés IC, König A, Outeiro TF.
    Glycation in Huntington’s Disease: A Possible Modifier and Target for Intervention.
    J Huntingtons Dis. 2019 Jul 16. doi: 10.3233/JHD-190366. [Epub ahead of print](PubMed)
  • Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M.
    A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria.
    J Mol Biol. 2019 Jul 12;431(15):2835-2851. doi: 10.1016/j.jmb.2019.05.015. Epub 2019 May 17.(PubMed)
  • Fornasiero EF, Rizzoli SO.
    Pathological changes are associated with shifts in the employment of synonymous codons at the transcriptome level.
    BMC Genomics. 2019 Jul 9;20(1):566. doi: 10.1186/s12864-019-5921-9.(PubMed)
  • Delenclos M, Burgess JD, Lamprokostopoulou A, Outeiro TF, Vekrellis K, McLean PJ.
    Cellular models of alpha-synuclein toxicity and aggregation.
    J Neurochem. 2019 Jul 2. doi: 10.1111/jnc.14806. [Epub ahead of print](PubMed)
  • Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, Thom T, Rizzoli S, Schmitz M, Li J, Zerr I, Attems J, Jahn O, Outeiro TF.
    Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
    Cell Rep. 2019 Jul 2;28(1):65-77.e6. doi: 10.1016/j.celrep.2019.06.009.(PubMed)
  • Rossetti G, Kless A, Lai L, Outeiro TF, Carloni P.
    Investigating targets for neuropharmacological intervention by molecular dynamics simulations.
    Biochem Soc Trans. 2019 Jun 28;47(3):909-918. doi: 10.1042/BST20190048. Epub 2019 May 13.(PubMed)
  • Outeiro TF, Harvey K, Dominguez-Meijide A, Gerhardt E.
    LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?
    Biochem Soc Trans. 2019 Jun 28;47(3):827-838. doi: 10.1042/BST20180466. Epub 2019 May 13.(PubMed)
  • Kaltschnee L, Jagtap A, McCormick J, Bouchard L, Wagner S, Utz M, Griesinger C, Glöggler S.
    Hyperpolarization of Amino Acids in Water Utilizing Parahydrogen on a Rhodium Nanocatalyst.
    SFX-Linkservice der SUB Goettingen 25 June 2019. doi.org/10.1002/chem.201902878.
  • Richter KN, Patzelt C, Phan NTN, Rizzoli SO.
    Antibody-driven capture of synaptic vesicle proteins on the plasma membrane enables the analysis of their interactions with other synaptic proteins.
    Sci Rep. 2019 Jun 25;9(1):9231. doi: 10.1038/s41598-019-45729-4.(PubMed)
  • Berner S, Schmidt AB, Zimmermann M, Pravdivtsev AN, Glöggler S, Hennig J, Elverfeldt D, Hövener JB.
    SAMBADENA Hyperpolarization of 13C‐Succinate in an MRI: Singlet‐Triplet Mixing Causes Polarization Loss.
    SFX-Linkservice der SUB Goettingen 04 June 2019. doi.org/10.1002/open.201900139.
  • Elliot SJ, Kadeřáve P, Brown LJ, Sabba M, Glöggler S, O’Leary DJ, Brown RCD, Ferrage F, Levitt MH.
    Field-cycling long-lived-state NMR of 15N2 spin pairs.
    Molecular Physics 117 (7-8), pp. 861 – 867 (2019)
  • Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY.
    Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.
    Transl Neurodegener. 2019 Jun 15;8:18. doi: 10.1186/s40035-019-0159-7. eCollection 2019.(PubMed)
  • Burk K, Pasterkamp RJ.
    Disrupted neuronal trafficking in amyotrophic lateral sclerosis.
    Acta Neuropathol. 2019 Jun;137(6):859-877. doi: 10.1007/s00401-019-01964-7. Epub 2019 Feb 5. (PubMed)
  • Markworth R, Adolfs Y, Dambeck V, Steinbeck LM, Lizé M, Pasterkamp RJ, Bähr M, Dean C, Burk K.
    Sensory axon growth requires spatiotemporal integration of CaSR and TrkB signalling.
    J Neurosci. 2019 May 23. pii: 0027-19. doi: 10.1523/JNEUROSCI.0027-19.2019. [Epub ahead of print] (PubMed)
  • Seitz KJ, Rizzoli SO.
    GFP nanobodies reveal recently-exocytosed pHluorin molecules.
    Sci Rep. 2019 May 23;9(1):7773. doi: 10.1038/s41598-019-44262-8. (PubMed)
  • González N, Arcos-López T, König A, Quintanar L, Menacho Márquez M, Outeiro TF, Fernández CO.
    Effects of alpha-synuclein post-translational modifications on metal binding.
    J Neurochem. 2019 May 16. doi: 10.1111/jnc.14721. [Epub ahead of print] (PubMed)
  • Gong J, Szego ÉM, Leonov A, Benito E, Becker S, Fischer A, Zweckstetter M, Outeiro T, Schneider A.
    Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism.
    J Neurosci. 2019 May 8;39(19):3752-3769. doi: 10.1523/JNEUROSCI.2070-18.2019. Epub 2019 Feb 22. (PubMed)
  • Candelise N, Schmitz M, Llorens F, Villar-Piqué A, Cramm M, Thom T, da Silva Correia SM, da Cunha JEG, Möbius W, Outeiro TF, Álvarez VG, Banchelli M, D’Andrea C, de Angelis M, Zafar S, Rabano A, Matteini P, Zerr I.
    Seeding variability of different alpha synuclein strains in synucleinopathies.
    Ann Neurol. 2019 May;85(5):691-703. doi: 10.1002/ana.25446. Epub 2019 Mar 27.(PubMed)
  • Agüi-Gonzalez P, Jähne S, Phan NTN. (2019)
    SIMS imaging in neuro- and cell biology.
    J Anal At Spectrom, DOI: 10.1039/C9JA00118B
  • Kabatas S, Agüi-Gonzalez P, Hinrichs R, Jähne S, Opazo F, Diederichsen U, Rizzoli SO, Phan NTN. (2019)
    Fluorinated nanobodies for targeted molecular imaging of biological samples using nanoscale secondary ion mass spectrometry.
    J Anal At Spectrom 34:1083-1087
  • Chakrabarti R, Wichmann C.
    Nanomachinery Organizing Release at Neuronal and Ribbon Synapses.
    Int J Mol Sci. 2019 Apr 30;20(9). pii: E2147. doi: 10.3390/ijms20092147. (PubMed)
  • Vasili E, Dominguez-Meijide A, Outeiro TF.
    Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.
    Front Mol Neurosci. 2019 Apr 25;12:107. doi: 10.3389/fnmol.2019.00107. eCollection 2019.(PubMed)
  • Carija A, Pinheiro F, Pujols J, Brás IC, Lázaro DF, Santambrogio C, Grandori R, Outeiro TF, Navarro S, Ventura S.
    Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity.
    Redox Biol. 2019 Apr;22:101135. doi: 10.1016/j.redox.2019.101135. Epub 2019 Feb 5. (PubMed)
  • Marvian AT, Koss DJ, Aliakbari F, Morshedi D, Outeiro TF.
    In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies.
    J Neurochem. 2019 Apr 20. doi: 10.1111/jnc.14707. [Epub ahead of print](PubMed)
  • Michanski S, Smaluch K, Steyer AM, Chakrabarti R, Setz C, Oestreicher D, Fischer C, Möbius W, Moser T, Vogl C, Wichmann C.
    Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea.
    Proc Natl Acad Sci U S A. 2019 Mar 13. pii: 201812029. doi: 10.1073/pnas.1812029116. [Epub ahead of print] (PubMed)
  • Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG.
    A practical guide to optimization in X10 expansion microscopy.
    Nat Protoc. 2019 Mar;14(3):832-863. doi: 10.1038/s41596-018-0117-3. (PubMed)
  • Kabatas S, Agüi-Gonzalez P, Saal KA, Jähne S, Opazo F, Rizzoli SO, Phan NTN.
    Boron-Containing Probes for Non-optical High-Resolution Imaging of Biological Samples.
    Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3438-3443. doi: 10.1002/anie.201812032. Epub 2019 Feb 6. (PubMed)
  • Kroll J, Jaime Tobón LM, Vogl C, Neef J, Kondratiuk I, König M, Strenzke N, Wichmann C, Milosevic I, Moser T.
    Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells.
    EMBO J. 2019 Mar 1;38(5). pii: e100116. doi: 10.15252/embj.2018100116. Epub 2019 Feb 7. (PubMed)
  • Maidorn M, Olichon A, Rizzoli SO, Opazo F.
    Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons.
    MAbs. 2019 Feb/Mar;11(2):305-321. doi: 10.1080/19420862.2018.1551675. Epub 2018 Dec 28. (PubMed)
  • Yang S, McCormick J, Mamone S, Bouchard LS, Glöggler S.
    Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Switch for Spin Singlet States.
    Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2879-2883. doi: 10.1002/anie.201814198. Epub 2019 Jan 28. (PubMed)
  • Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A.
    β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.
    Nature. 2019 Feb;566(7745):503-508. doi: 10.1038/s41586-019-0964-2. Epub 2019 Feb 20.(PubMed)
  • Gomes de Castro MA, Wildhagen H, Sograte-Idrissi S, Hitzing C, Binder M, Trepel M, Engels N, Opazo F.
    Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane.
    Nat Commun. 2019 Feb 18;10(1):820. doi: 10.1038/s41467-019-08677-1. (PubMed)
  • Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, Donaghy P, Morris C, Taylor JP, Thomas A, Attems J, McKeith I.
    Dementia with Lewy bodies: an update and outlook.
    Mol Neurodegener. 2019 Jan 21;14(1):5. doi: 10.1186/s13024-019-0306-8. (PubMed)
  • Sograte-Idrissi S, Oleksiievets N, Isbaner S, Eggert-Martinez M, Enderlein J, Tsukanov R, Opazo F.
    Nanobody Detection of Standard Fluorescent Proteins Enables Multi-Target DNA-PAINT with High Resolution and Minimal Displacement Errors.
    Cells. 2019 Jan 14;8(1). pii: E48. doi: 10.3390/cells8010048. (PubMed)
  • Glöggler S, Yang S, McCormick J, Mamone S, Bouchard LS.
    Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Spin Singlet State Switch.
    Angew Chem Int Ed Engl. 2019 Jan 10. doi: 10.1002/anie.201814198. [Epub ahead of print] (PubMed)
  • Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.
    Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.
    Hum Mol Genet. 2019 Jan 1;28(1):31-50. doi: 10.1093/hmg/ddy326. (PubMed)
  • Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL.
    Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding
    Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. Epub 2018 Nov 15 (PubMed)
  • Brás IC, Popova B, Braus GH, Outeiro TF.
    Yeast-Based Screens to Target Alpha-Synuclein Toxicity.
    Methods Mol Biol. 2019;1948:145-156. doi: 10.1007/978-1-4939-9124-2_12.(PubMed)
  • Saul P, Mamone S, Glöggler S.
    Nuclear spin singlet multimers (NUSIMERs) with long-lived singlet states.
    Chem. Sci. 10, 413-417 (2019)

  • 2018

    • Harvey K, Outeiro TF.
      The role of LRRK2 in cell signalling.
      Biochem Soc Trans. 2018 Dec 21. pii: BST20180464. doi: 10.1042/BST20180464. [Epub ahead of print] Review. (PubMed)
    • Saal K-A, Richter F, Rehling P, Rizzoli SO.
      Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry
      ACS Nano 2018 Dec 10 DOI:10.1021/acsnano.8b06047 [Epub ahead of print] (PubMed)
    • Brás IC, Tenreiro S, Silva AM, Outeiro TF.
      Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast.
      FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy108. (PubMed)
    • Brás IC, Lopes LV, Outeiro TF.
      Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration.
      Mov Disord. 2018 Nov;33(11):1675-1684. doi: 10.1002/mds.27478. Epub 2018 Nov 13. (PubMed)
    • Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF.
      Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
      Neurobiol Dis. 2018 Nov;119:121-135. doi: 10.1016/j.nbd.2018.08.001. Epub 2018 Aug 6.(PubMed)
    • Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF.
      The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
      Sci Rep. 2018 Nov 15;8(1):16913. doi: 10.1038/s41598-018-35277-8. (PubMed)
    • Gustafsson G, Lööv C, Persson E, Lázaro DF, Takeda S, Bergström J, Erlandsson A, Sehlin D, Balaj L, György B, Hallbeck M, Outeiro TF, Breakefield XO, Hyman BT, Ingelsson M.
      Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.
      Cell Mol Neurobiol. 2018 Nov;38(8):1539-1550. doi: 10.1007/s10571-018-0622-5. Epub 2018 Oct 4. (PubMed)
    • Rink WM, Thomas F.
      Decoration of Coiled-Coil Peptides with N-Cysteine Peptide Thioesters As Cyclic Peptide Precursors Using Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) Click Reaction.
      Org Lett. 2018 Nov 8. DOI: 10.1021/acs.orglett.8b03261 [Epub ahead of print] (PubMed)
    • Elliott SJ, Kaderavek P, Brown LJ, Sabba M, Glöggler S, O’Leary DJ, Brown RCD, Ferrage F, Levitt MH.
      Field-cycling long-lived-state NMR of 15N2 spin pairs.
      Mol. Phys. DOI: 10.1080/00268976.2018.1543906 (2018). ()
    • Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO.
      Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.
      Nat Commun. 2018 Oct 12;9(1):4230. doi: 10.1038/s41467-018-06519-0. (PubMed)
    • Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfó E, Ventura S.
      Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
      Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486. doi: 10.1073/pnas.1804198115. Epub 2018 Sep 24. (PubMed)
    • Prasad V, Wasser Y, Hans F, Goswami A, Katona I, Outeiro TF, Kahle PJ, Schulz JB, Voigt A.
      Monitoring α-synuclein multimerization in vivo.
      FASEB J. 2018 Sep 25:fj201800148RRR. doi: 10.1096/fj.201800148RRR. [Epub ahead of print] (PubMed)
    • Chakrabarti R, Michanski S, Wichmann C.
      Vesicle sub-pool organization at inner hair cell ribbon synapses.
      (2018) EMBO Rep. 2018 Sep 10. pii: e44937. DOI:10.15252/embr.201744937 [Epub ahead of print] (PubMed)
    • Roser AE, Caldi Gomes L, Schünemann J, Maass F, Lingor P.
      Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease.
      Front Neurosci. 2018 Sep 5;12:625. doi: 10.3389/fnins.2018.00625. eCollection 2018. (PubMed)
    • Magalhães RSS, Popova B, Braus GH, Outeiro TF, Eleutherio ECA.
      The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.
      FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy066. (PubMed)
    • Hövener JB, Pravdivtsev AN, Kidd B, Bowers CR, Glöggler S, Kovtunov KV, Plaumann M, Katz-Brull R, Buckenmaier K, Jerschow A, Reineri F, Theis T, Shchepin RV, Wagner S, Bhattacharya P, Zacharias NM, Chekmenev EY.
      Parahydrogen-Based Hyperpolarization for Biomedicine.
      Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201711842. (PubMed)
    • Mann FA, Horlebein J, Meyer NF, Meyer D, Thomas F, Kruss S.
      Carbon Nanotubes Encapsulated in Coiled-Coil Peptide Barrels.
      Chem. Eur. J. 2018, DOI: 10.1002/chem.201800993. Cover feature (PubMed)
    • Mamone S, Glöggler S.
      Nuclear spin singlet states as magnetic on/off probes in self-assembling systems.
      Phys. Chem. Chem. Phys., 2018, DOI: 10.1039/C8CP04448A. (pubs.rsc)
    • Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF.
      Membrane binding, internalization, and sorting of alpha-synuclein in the cell.
      Acta Neuropathol Commun. 2018 Aug 14;6(1):79. doi: 10.1186/s40478-018-0578-1. (PubMed)
    • Rink WM, Thomas F.
      De novo designed α-helical coiled-coil peptides as scaffolds for chemical reactions.
      Chem. Eur. J. 2018, DOI: 10.1002/chem.201802849. (PubMed)
    • Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF.
      Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
      Neurobiol Dis. 2018 Aug 6;119:121-135. doi: 10.1016/j.nbd.2018.08.001. (PubMed)
    • Korchak S, Mamone S, Glöggler S.
      Over 50 % 1H and 13C Polarization for Generating Hyperpolarized Metabolites—A para‐Hydrogen Approach.
      ChemistryOpen. 2018, DOI: 10.1002/chem.201800086. (Wiley online library)
    • Truckenbrodt S, Maidorn M, Crzan D, Wildhagen H, Kabatas S, Rizzoli SO.
      X10 expansion microscopy enables 25-nm resolution on conventional microscopes.
      EMBO Rep. 2018 Jul 9. pii: e45836. doi: 10.15252/embr.201845836. (PubMed)
    • Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO.
      Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
      EMBO J. 2018 Aug 1;37(15). pii: e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27. (PubMed)
    • Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V,Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.
      Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
      Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print] (PubMed)
    • McCormick J, Korchak S, Mamone S, Ertas YN, Liu Z, Verlinsky L, Wagner S, Glöggler S, Bouchard LS.
      More Than 12% Polarization and 20 Minutes Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water.
      Angew. Chem. Int. Ed. 2018, 57, 10692-10696. (PubMed)
    • Roser AE, Caldi Gomes L, Halder R, Jain G, Maass F, Tönges L, Tatenhorst L, Bähr M, Fischer A, Lingor P.
      miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.
      Mol Ther Nucleic Acids. 2018 Jun 1;11:9-22. doi: 10.1016/j.omtn.2018.01.005. Epub 2018 Feb 2. (PubMed)
    • Vaz RL, Outeiro TF, Ferreira JJ.
      Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review.
      Front Neurol. 2018 Jun 1;9:347. doi: 10.3389/fneur.2018.00347. eCollection 2018. (PubMed)
    • Korchak S, Yang S, Mamone S, Glöggler S.
      Pulsed Magnetic Resonance to Signal-Enhance Metabolites within Seconds by utilizing para-Hydrogen.
      ChemistryOpen. 2018 May 8;7(5):344-348. doi: 10.1002/open.201800024. eCollection 2018 May. (PubMed)
    • Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE,Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN.
      (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.
      Sci Rep. 2018 May 3;8(1):6965. doi: 10.1038/s41598-018-25118-z. (PubMed)
    • Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.
      The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
      Mol Neurobiol. 2018 Apr 19. doi:10.1007/s12035-018-1084-y. (PubMed)
    • Groth MC, Rink WM, Meyer NF, Thomas F.
      Kinetic Studies on Strand Displacement in de novo Designed Parallel Heterodimeric Coiled Coils.
      Chem. Sci. 2018, 9, 4308–4316. (PubMed)
    • Biosa A, Outeiro TF, Bubacco L, Bisaglia M.
      Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View.
      Mol Neurobiol. 2018 Mar 28. doi: 10.1007/s12035-018-1025-9. [Epub ahead of print] Review. (PubMed)
    • Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO.
      Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.
      Biophys J. 2018 Mar 13;114(5):1036-1045. doi: 10.1016/j.bpj.2018.01.003. (PubMed)
    • Fourcade S, Outeiro TF, Pujol A.
      SIRT2 in age-related neurodegenerative disorders.
      Aging (Albany NY). 2018 Mar 3;10(3):295-296. doi:10.18632/aging/101397. (PubMed)
    • König A, Vicente Miranda H, Outeiro TF.
      Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease.
      J Parkinsons Dis. 2018;8(1):33-43. doi: 10.3233/JPD-171285. (PubMed)
    • Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, Wichmann C, Strenzke N, Grabner C, Moser T.
      The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
      Elife. 2018 Jan 12;7. pii: e29275. doi: 10.7554/eLife.29275. (PubMed)
    • Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C,Meyer T.
      Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study.
      World J Biol Psychiatry. 2018 Jan 11:1-9. doi: 10.1080/15622975.2017.1417636. [Epub ahead of print] (PubMed)
    • Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.
      Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
      EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.(PubMed)
    • Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.
      Guidelines and recommendations on yeast cell death nomenclature.
      Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review. (PubMed)

    2017

    • Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Gonçalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltényi G, Borovecki F, Soreq H, Ferreira JJ, Outeiro TF.
      Correction: Gene Expression Differences in Peripheral Blood of Parkinson’s Disease Patients with Distinct Progression Profiles.
      PLoS One. 2017 Dec 28;12(12):e0190552. doi: 10.1371/journal.pone.0190552. eCollection 2017 (PubMed)
    • Bozek T, Blazekovic A, Perkovic MN, Jercic KG, Sustar A, Smircic-Duvnjak L, Outeiro TF, Pivac N, Borovecki F.
      The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus.
      Diabetol Metab Syndr. 2017 Dec 4;9:97. doi: 10.1186/s13098-017-0295-0. eCollection 2017. (PubMed)
    • Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al’Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA,Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.
      Building Bridges through Science.
      Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028. (PubMed)
    • Krinner S, Butola T, Jung S, Wichmann C, Moser T.
      RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.
      Front Cell Neurosci. 2017 Nov 2;11:334. doi: 10.3389/fncel.2017.00334. eCollection 2017. (PubMed)
    • Lemos V, de Oliveira RM, Naia L, Szegö É, Ramos E, Pinho S, Magro F, Cavadas C, Rego AC, Costa V, Outeiro TF, Gomes P.
      The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
      Hum Mol Genet. 2017 Nov 1;26(21):4105-4117. doi: 10.1093/hmg/ddx298. (PubMed)
    • Guedes LC, Chan RB, Gomes MA, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Carriço JA, Alcalay RN, Ferreira JJ, Outeiro TF, Miltenberger-Miltenyi G.
      Serum lipid alterations in GBA-associated Parkinson’s disease.
      Parkinsonism Relat Disord. 2017 Nov;44:58-65. doi: 10.1016/j.parkreldis.2017.08.026. Epub 2017 Sep 1. (PubMed)
    • López-León M, Outeiro TF, Goya RG.
      Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain.
      Ageing Res Rev. 2017 Nov;40:168-181. doi: 10.1016/j.arr.2017.09.002. Epub 2017 Sep 10. Review. (PubMed)
    • Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.
      α-synuclein interacts with PrP(C) to induce cognitive impairment through mGluR5 and NMDAR2B.
      Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25. (PubMed)
    • Butola T, Wichmann C, Moser T.
      Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.
      Front Synaptic Neurosci. 2017 Oct 25;9:14. doi: 10.3389/fnsyn.2017.00014. eCollection 2017. (PubMed)
    • Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF.
      Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease.
      Sci Rep. 2017 Oct 20;7(1):13713. doi: 10.1038/s41598-017-14175-5. (PubMed)
    • Roodveldt C, Outeiro TF, Braun JEA.
      Editorial: Molecular Chaperones and Neurodegeneration.
      Front Neurosci. 2017 Oct 11;11:565. doi: 10.3389/fnins.2017.00565. eCollection 2017. (PubMed)
    • Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.
      Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.
      Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260. (PubMed)
    • Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA.
      Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.
      Mol Neurobiol. 2018 Jun;55(6):5269-5281. doi: 10.1007/s12035-017-0755-4. Epub 2017 Sep 7. (PubMed)
    • Correia Guedes L, Reimão S, Paulino P, Nunes RG, Bouça-Machado R, Abreu D, Gonçalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, Campos J, Outeiro TF, Sampaio C, Bonifati V, Ferreira JJ.
      Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson’s disease.
      Mov Disord. 2017 Sep;32(9):1331-1333. doi: 10.1002/mds.27083. Epub 2017 Jul 7. (PubMed)
    • Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego ÉM, Kerimoglu C, Gerhardt E, Rego AC, Fischer A, Bonn S, Outeiro TF.
      Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.
      Hum Mol Genet. 2017 Jun 15;26(12):2231-2246. doi: 10.1093/hmg/ddx114. (PubMed)
    • Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.
      Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
      Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056. (PubMed)
    • de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.
      The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
      PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar.(PubMed)
    • Gomes de Castro MA, Höbartner C, Opazo F.
      Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy.
      PLoS One. 2017 Feb 24;12(2):e0173050. doi: 10.1371/journal.pone.0173050. eCollection 2017. (PubMed)

    2016

    • Maidorn M, Rizzoli SO, Opazo F.
      Tools and limitations to study the molecular composition of synapses by fluorescence microscopy.
      Biochem J. 2016 Oct 15;473(20):3385-3399. Review. (PubMed)